T16: Mixed types from T12-T18

50. Pharmacokinetics 50.1) PK Basic parameters 50.1.3) Area Under Curve (AUC)

50.1.3.1) AUC basic concepts Normal 1


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The elimination rate constant of a drug is 0.123 h-1. It is parenterally administered to a patient weighing 199 Kg. If the volume of distribution of the drug is 0.56 L/Kg, and the AUC was measured to be 20.16 mg × h/L, then determine the amount of dose the patient received.


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lb equals 276.371 mg kg

    We know that:
    `AUC=(dose)/(cl earance)=(dose)/(K × V)`.

    Rearranging the equation: `dose=AUC × K × V`.

    However, the total volume of distribution (V) will be equal to the volume of distribution per Kg body weight times the weight of the patient in Kg.

    `∴ dose=`

    `(20.16 \quad mg × h)/L × 0.123/h × (0.56 \quad L)/(Kg) × 199 \quad Kg`

    `∴ dose= 276.37 \quad mg`. Ans.

    Clarification: The AUC shown in this question (20.16) has been rounded from its more precise value (20.162601626016), that is why the displayed answer looks slightly distorted.


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