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Reduce kidney

6. Patient-based Dose 6.4) Disease state 6.4.1) Disease State

6.4.1.1) Reduce Dose Normal 3


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The adult dose of a drug is 400 mg every 24 hours. For an elderly patient with impaired renal function, the dose is reduced to 100 mg every 12 hours. Calculate the percentage reduction in the daily dose.


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lb equals 50.00% kg

Adult total dose = `(400 mg) / (24 hr) × (24 hr) / (1 day)` = 400 `(mg) / (day)`

Reduced total dose = `(100 mg) / (12 hr) × (24 hr) / (1 day)` = 200 `(mg) / (day)`

Amount reduced = 400 mg – 200 mg = 200 mg

The percentage reduction in the daily dose

= `(200 mg)/(400 mg) × 100 %` = 50.00 % Ans.




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