### Regimen: Stanford V for Hodgkin lymphoma PO dose

6. Patient-based Dose 6.5) Chemo Dose Clculation 6.5.5) PO dose of Stanford V

6.5.4.1) PO dose per cycle of Stanford V Normal 1

Total tried:       Correct:       Wrong:

Regimen : Stanford V for Hodgkin lymphoma.
Cycle: three 4-week cycles. Total regimen is 12 weeks.

• Doxorubicin, 25 mg/m2, IV, weeks 1, 3, 5, 7, 9 and 11
• Mechlorethamine, 6 mg/m2, IV, weeks 1, 5 and 9
• Vinblastine, 6 mg/m2, IV, weeks 1, 3, 5, 7, 9 and 11
• Vincristine, 1.61 mg/m2, IV, weeks 2, 4, 6, 8, 10 and 12.
• Bleomycin, 5 units/m2 , IV, weeks 2, 4, 6, 8, 10 and 12.
• Etoposide, 60 mg/m2 per day IV on 2 consecutive days in weeks 3, 7, 11
• Prednisone, 40 mg/m2 PO every other day for 10 weeks then tapered by 10 mg PO every other day between week 10 and 12
For prednisone calculate the total PO dose in 12 weeks for a patient measuring 6 feet 2 inches in height and weighing 389 lb. Click on the button below to see the answer and explanations

lb equals 4802.00 mg kg

• The patient height
= 6 feet 2 inches
= ( 6 × 12 + 2 ) inch
= 74 inch
= 74 × 2.54 cm
= 187.96 cm

• patient weight
= 389 lb
= 389 × 0.454 kg
= 176.6 kg

• BSA for the patient is

BSA = \quad sqrt(( Height (cm) × Weight (Kg) )/(3600))

 \quad \quad \quad = sqrt(( 187.96 \quad cm × 176.6 \quad Kg )/(3600)) = 3.0365  m2

• ### Here for prednisone :

patient dose for every other day
= ( 40 \quad mg)/(1quad m^2) × 3.0365 m^2
= 121  mg

Hence, dose for first 10 weeks
=  121 \quad mg × 35 (days of treatment)
= 4235 mg

And dose for 11^(th) and 12^(th) weeks (7 days of treatment tapered by 10 mg)
= ( 111 + 101 + 91 + 81 + 71 + 61 + 51 ) mg
= 567 mg

Therefore, total dose for 12 weeks cycle
= 4235 mg + 567 mg = 4802 mg Ans.