T01) Find Ct from C0, k and t
50. Pharmacokinetics 50.2) Plasma concentrations over time 50.2.1) Plasma concentrations over time
T01: Later plasma concentration Normal 1
Total tried: Correct: Wrong:
A 164 Kg patient was intravenously administered a drug. The plasma concentration was found to be 4.12 mg/L, when the blood was first collected. If the drug follows a first order elimination and the elimination rate constant (k) is `0.295 \quad h^{-1}`, then determine the plasma concentration after 1.5 hours.
Click on the button below to see the answer and explanations
lb equals 2.647 mg/L kg
-
For a first order process,
`C_{t}=C_{0}×e^(-kt)`
Plugging the values in this equation, we get:
`C_{t}=4.12 × e^(- 0.295 × 1.5)`
`∴ C_{t}=2.647`
Thus, the later concentration is: 2.647 mg/L. (Ans).