T14: V from Dose, AUC and K

50. Pharmacokinetics 50.1) PK Basic parameters 50.1.3) Area Under Curve (AUC) AUC basic concepts Normal 1

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The elimination rate constant of a drug is 0.042 h-1. Determine its volume of distribution in a patient who received 335.85 mg of the drug parenterally and the AUC was found to be 106.9 mg × h/L.

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lb equals 74.8 L kg

    We know that, `AUC = (dose)/(cl earance)`

    However, Cl is the product of elimination rate constant (K) and volume of distribution (V).

    `⇒ AUC=(dose)/(K × V)`.

    `⇒ V=(dose)/(K × AUC)`

    Plugging the values in this equation we get:
    ` V = (335.85 \quad mg)/(0.042 \quad h^{-1} × 106.9 (mg × h)/L)`

    ` ∴ V=74.8 \quad L`. Ans.