T08: Clearance from K, dose and concentration
50. Pharmacokinetics 50.1) PK Basic parameters 50.1.2) Clearance
50.1.2.1) Clearance basic concepts Normal 1
Total tried: Correct: Wrong:
19.25 mg of a drug was administered to a patient as an IV push, which resulted the plasma concentration of 0.27 mg/L. The elimination rate constant of the drug is 0.08 h-1. Determine the clearance of the drug in this patient.
Click on the button below to see the answer and explanations
lb equals 5.704 L/h kg
-
We know that, clearance (Cl) is the product of elimination rate constant (K) and volume of distribution (V).
` Cl = K × V `.
In this case, we hav the dose of the drug administered (`X_{0}`) and the plasma concentration (`C_{0}`). We know that:
`C_{0} = X_{0}/V ⇒ V = X_{0}/C_{0}`.
Therefore, clearance (Cl) will be:
`Cl = 0.08 \quad h^{-1} \quad × (19.25 \quad mg)/(0.27 \quad (mg)/L) = 5.7 \quad L/h`. Ans