T05: (1→5) Mixed types of problems

50. Pharmacokinetics 50.1) PK Basic parameters 50.1.2) Clearance

50.1.2.1) Clearance basic concepts Normal 1


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The elimination rate constant of a drug is 0.037 h-1. Determine the half life of the drug.


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lb equals 18.73 h kg

    The relationship between elimination rate constant, `K` and plasma half life, `t_{½}` is, `t_{½}=0.693/K`.

    Plugging the value of K in this equation we get:

    `t_{½}=0.693/(0.037/h)`.
    `therefore t_{½}= 18.73 \quad h`. Ans.