T05: (1→5) Mixed types of problems
50. Pharmacokinetics 50.1) PK Basic parameters 50.1.2) Clearance
50.1.2.1) Clearance basic concepts Normal 1
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Determine the elimination rate constant of a drug if its plasma half life is 4.28 h
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lb equals 0.162 h-1 kg
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The relationship between elimination rate constant, `K` and plasma half life, `t_{½}` is, `t_{½}=0.693/K`.
`Rightarrow K=0.693/t_{½}`
Plugging the value of `t_{½}` in this equation we get:
`K = 0.693/(4.28 \quad h)`.
`therefore` K=0.162 h-1. Ans.