Regimen : MAVC for metastatic transitional cell bladder cancer.
6. Patient-based Dose 6.5) Chemo Dose Clculation 6.5.3) Intravenous dose of MVAC
6.5.3.1) Intravenous dose per cycle of MVAC Normal 1
Total tried: Correct: Wrong:
Regimen : MAVC for metastatic transitional cell bladder cancer.
Cycle: 28 days, repeat every 28 days for 4-6 cycles
- Doxorubicin, 30 mg/m2, slow IV push, D 2
- Vinblastin, 3 mg/m2, IV , D 2,15,22
- Methotrexate, 30 mg/m2, slow IV push, D 1, 15, 22
- Cisplatin, 70 mg/m2, IV , D 2
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lb equals 57.35 mg and 172.04 mg kg
- The patient height
= 5 feet 1 inches
= ( 5 × 12 + 1 ) inch
= 61 inch
= 61 × 2.54 cm
= 154.94 cm - patient weight
= 187 lb
= 187 × 0.454 kg
= 84.9 kg -
BSA for the patient is
BSA `= \quad sqrt(( Height (cm) × Weight (Kg) )/(3600))`
` \quad \quad \quad = sqrt(( 154.94 \quad cm × 84.9 \quad Kg )/(3600)) = 1.9115 ` m2
-
For Doxorubicin :
`( 30 \quad mg)/( 1 \quad m^2 )` × 1.9115 m2 × 1 (days of treatment) = 57.345 mg
-
For Methotrexate :
`( 30 \quad mg)/( 1 \quad m^2 )` × 1.9115 m2 × 3 (days of treatment) = 172.035 mg
`\quad \quad \quad` 57.35 mg and 172.04 mg `Ans.`