### Regimen : MAVC for metastatic transitional cell bladder cancer.

6. Patient-based Dose 6.5) Chemo Dose Clculation 6.5.3) Intravenous dose of MVAC

6.5.3.1) Intravenous dose per cycle of MVAC Normal 1

Total tried:       Correct:       Wrong:

Regimen : MAVC for metastatic transitional cell bladder cancer.
Cycle: 28 days, repeat every 28 days for 4-6 cycles

• Doxorubicin, 30 mg/m2, slow IV push, D 2
• Vinblastin, 3 mg/m2, IV , D 2,15,22
• Methotrexate, 30 mg/m2, slow IV push, D 1, 15, 22
• Cisplatin, 70 mg/m2, IV , D 2
For doxorubicin, methotrexate and cisplatin calculate total intravenous dose per cycle for a patient measuring 5 feet 10 inches in height and weighing 160 lb.

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lb equals 56.81 mg, 170.42 mg and 132.55 mg kg

• The patient height
= 5 feet 10 inches
= ( 5 × 12 + 10 ) inch
= 70 inch
= 70 × 2.54 cm
= 177.8 cm

• patient weight
= 160 lb
= 160 × 0.454 kg
= 72.6 kg

• BSA for the patient is

BSA = \quad sqrt(( Height (cm) × Weight (Kg) )/(3600))

 \quad \quad \quad = sqrt(( 177.8 \quad cm × 72.6 \quad Kg )/(3600)) = 1.8936  m2

• For Doxorubicin :
( 30 \quad mg)/( 1 \quad m^2 ) × 1.8936 m2 × 1 (days of treatment) = 56.808 mg

• For Methotrexate :
( 30 \quad mg)/( 1 \quad m^2 ) × 1.8936 m2 × 3 (days of treatment) = 170.424 mg

• For Cisplatin :
( 70 \quad mg)/( 1 \quad m^2 ) × 1.8936 m2 × 1 (days of treatment) = 132.552 mg

\quad \quad Therefore,
\quad \quad \quad 56.81 mg, 170.42 mg and 132.55 mg Ans.