Regimen : MAVC for metastatic transitional cell bladder cancer.

6. Patient-based Dose 6.5) Chemo Dose Clculation 6.5.3) Intravenous dose of MVAC

6.5.3.1) Intravenous dose per cycle of MVAC Normal 1


Total tried:       Correct:       Wrong:

Regimen : MAVC for metastatic transitional cell bladder cancer.
Cycle: 28 days, repeat every 28 days for 4-6 cycles

  • Doxorubicin, 30 mg/m2, slow IV push, D 2
  • Vinblastin, 3 mg/m2, IV , D 2,15,22
  • Methotrexate, 30 mg/m2, slow IV push, D 1, 15, 22
  • Cisplatin, 70 mg/m2, IV , D 2
For doxorubicin, methotrexate and cisplatin calculate total intravenous dose per cycle for a patient measuring 5 feet 10 inches in height and weighing 160 lb.


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lb equals 56.81 mg, 170.42 mg and 132.55 mg kg

  • The patient height
    = 5 feet 10 inches
    = ( 5 × 12 + 10 ) inch
    = 70 inch
    = 70 × 2.54 cm
    = 177.8 cm

  • patient weight
    = 160 lb
    = 160 × 0.454 kg
    = 72.6 kg

  • BSA for the patient is

    BSA `= \quad sqrt(( Height (cm) × Weight (Kg) )/(3600))`

    ` \quad \quad \quad = sqrt(( 177.8 \quad cm × 72.6 \quad Kg )/(3600)) = 1.8936 ` m2

  • For Doxorubicin :
    `( 30 \quad mg)/( 1 \quad m^2 )` × 1.8936 m2 × 1 (days of treatment) = 56.808 mg

  • For Methotrexate :
    `( 30 \quad mg)/( 1 \quad m^2 )` × 1.8936 m2 × 3 (days of treatment) = 170.424 mg

  • For Cisplatin :
    `( 70 \quad mg)/( 1 \quad m^2 )` × 1.8936 m2 × 1 (days of treatment) = 132.552 mg

`\quad \quad` Therefore,
`\quad \quad \quad` 56.81 mg, 170.42 mg and 132.55 mg `Ans.`