Regimen : MAVC for metastatic transitional cell bladder cancer.

6. Patient-based Dose 6.5) Chemo Dose Clculation 6.5.3) Intravenous dose of MVAC

6.5.3.1) Intravenous dose per cycle of MVAC Normal 1


Total tried:       Correct:       Wrong:

Regimen : MAVC for metastatic transitional cell bladder cancer.
Cycle: 28 days, repeat every 28 days for 4-6 cycles

  • Doxorubicin, 30 mg/m2, slow IV push, D 2
  • Vinblastin, 3 mg/m2, IV , D 2,15,22
  • Methotrexate, 30 mg/m2, slow IV push, D 1, 15, 22
  • Cisplatin, 70 mg/m2, IV , D 2
For vinblastin and cisplatin calculate total intravenous dose per cycle for a patient measuring 4 feet 10 inches in height and weighing 165 lb.


Click on the button below to see the answer and explanations

lb equals 15.76 mg and 122.55 mg kg

  • The patient height
    = 4 feet 10 inches
    = ( 4 × 12 + 10 ) inch
    = 58 inch
    = 58 × 2.54 cm
    = 147.32 cm

  • patient weight
    = 165 lb
    = 165 × 0.454 kg
    = 74.9 kg

  • BSA for the patient is

    BSA `= \quad sqrt(( Height (cm) × Weight (Kg) )/(3600))`

    ` \quad \quad \quad = sqrt(( 147.32 \quad cm × 74.9 \quad Kg )/(3600)) = 1.7507 ` m2

  • For Vinblastin :
    `( 3 \quad mg)/( 1 \quad m^2 )` × 1.7507 m2 × 3 (days of treatment) = 15.7563 mg

  • For Cisplatin :
    `( 70 \quad mg)/( 1 \quad m^2 )` × 1.7507 m2 × 1 (days of treatment) = 122.549 mg

`\quad \quad` Therefore,
`\quad \quad \quad` 15.76 mg and 122.55 mg `Ans.`