### Regimen : MAVC for metastatic transitional cell bladder cancer.

6. Patient-based Dose 6.5) Chemo Dose Clculation 6.5.3) Intravenous dose of MVAC

6.5.3.1) Intravenous dose per cycle of MVAC Normal 1

Total tried:       Correct:       Wrong:

Regimen : MAVC for metastatic transitional cell bladder cancer.
Cycle: 28 days, repeat every 28 days for 4-6 cycles

• Doxorubicin, 30 mg/m2, slow IV push, D 2
• Vinblastin, 3 mg/m2, IV , D 2,15,22
• Methotrexate, 30 mg/m2, slow IV push, D 1, 15, 22
• Cisplatin, 70 mg/m2, IV , D 2
For methotrexate calculate total intravenous dose per cycle for a patient measuring 5 feet 2 inches in height and weighing 242 lb. Click on the button below to see the answer and explanations

lb equals 197.33 mg kg

• The patient height
= 5 feet 2 inches
= ( 5 × 12 + 2 ) inch
= 62 inch
= 62 × 2.54 cm
= 157.48 cm

• patient weight
= 242 lb
= 242 × 0.454 kg
= 109.9 kg

• BSA for the patient is

BSA = \quad sqrt(( Height (cm) × Weight (Kg) )/(3600))

 \quad \quad \quad = sqrt(( 157.48 \quad cm × 109.9 \quad Kg )/(3600)) = 2.1926  m2

• For Methotrexate :
( 30 \quad mg)/( 1 \quad m^2 ) × 2.1926 m2 × 3 (days of treatment) = 197.334 mg

\quad \quad Therefore,
\quad \quad \quad 197.33 mg Ans.