Regimen : MAVC for metastatic transitional cell bladder cancer.

6. Patient-based Dose 6.5) Chemo Dose Clculation 6.5.3) Intravenous dose of MVAC

6.5.3.1) Intravenous dose per cycle of MVAC Normal 1


Total tried:       Correct:       Wrong:

Regimen : MAVC for metastatic transitional cell bladder cancer.
Cycle: 28 days, repeat every 28 days for 4-6 cycles

  • Doxorubicin, 30 mg/m2, slow IV push, D 2
  • Vinblastin, 3 mg/m2, IV , D 2,15,22
  • Methotrexate, 30 mg/m2, slow IV push, D 1, 15, 22
  • Cisplatin, 70 mg/m2, IV , D 2
For methotrexate calculate total intravenous dose per cycle for a patient measuring 5 feet 2 inches in height and weighing 242 lb.


Click on the button below to see the answer and explanations

lb equals 197.33 mg kg

  • The patient height
    = 5 feet 2 inches
    = ( 5 × 12 + 2 ) inch
    = 62 inch
    = 62 × 2.54 cm
    = 157.48 cm

  • patient weight
    = 242 lb
    = 242 × 0.454 kg
    = 109.9 kg

  • BSA for the patient is

    BSA `= \quad sqrt(( Height (cm) × Weight (Kg) )/(3600))`

    ` \quad \quad \quad = sqrt(( 157.48 \quad cm × 109.9 \quad Kg )/(3600)) = 2.1926 ` m2

  • For Methotrexate :
    `( 30 \quad mg)/( 1 \quad m^2 )` × 2.1926 m2 × 3 (days of treatment) = 197.334 mg

`\quad \quad` Therefore,
`\quad \quad \quad` 197.33 mg `Ans.`