T04) Plasma half life and elimination rate constant related

50. Pharmacokinetics 50.1) PK Basic parameters 50.1.2) Clearance

50.1.2.1) Clearance basic concepts Normal 1


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Determine the elimination rate constant of a drug if its plasma half life is 2.52 h


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lb equals 0.275 h-1 kg

    The relationship between elimination rate constant, `K` and plasma half life, `t_{½}` is, `t_{½}=0.693/K`.
    `Rightarrow K=0.693/t_{½}`
    Plugging the value of `t_{½}` in this equation we get:

    `K = 0.693/(2.52 \quad h)`.

    `therefore` K=0.275 h-1. Ans.