T04) Plasma half life and elimination rate constant related
50. Pharmacokinetics 50.1) PK Basic parameters 50.1.2) Clearance
50.1.2.1) Clearance basic concepts Normal 1
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The elimination rate constant of a drug is 0.102 h-1. Determine the half life of the drug.
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lb equals 6.79 h kg
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The relationship between elimination rate constant, `K` and plasma half life, `t_{½}` is, `t_{½}=0.693/K`.
Plugging the value of K in this equation we get:
`t_{½}=0.693/(0.102/h)`.
`therefore t_{½}= 6.79 \quad h`. Ans.