Regimen: Stanford V for Hodgkin lymphoma

6. Patient-based Dose 6.5) Chemo Dose Clculation 6.5.4) Intravenous dose of Stanford V

6.5.4.1) Intravenous dose per cycle of Stanford V Normal 1


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Regimen : Stanford V for Hodgkin lymphoma.
Cycle: three 4-week cycles. Total regimen is 12 weeks.

  • Doxorubicin, 25 mg/m2, IV, weeks 1, 3, 5, 7, 9 and 11
  • Mechlorethamine, 6 mg/m2, IV, weeks 1, 5 and 9
  • Vinblastine, 6 mg/m2, IV, weeks 1, 3, 5, 7, 9 and 11
  • Vincristine, 1.76 mg/m2, IV, weeks 2, 4, 6, 8, 10 and 12.
  • Bleomycin, 5 units/m2 , IV, weeks 2, 4, 6, 8, 10 and 12.
  • Etoposide, 60 mg/m2 per day IV on 2 consecutive days in weeks 3, 7, 11
  • Prednisone, 40 mg/m2 PO every other day for 10 weeks then tapered by 10 mg PO every other day between week 10 and 12
For doxorubicin, mechlorethamine and vinblastine calculate the total intravenous dose per cycle for a patient measuring 5 feet 6 inches in height and weighing 317 lb.


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lb equals 388.29 mg, 46.59 mg and 93.19 mg kg

  • The patient height
    = 5 feet 6 inches
    = ( 5 × 12 + 6 ) inch
    = 66 inch
    = 66 × 2.54 cm
    = 167.64 cm

  • patient weight
    = 317 lb
    = 317 × 0.454 kg
    = 143.9 kg

  • BSA for the patient is

    BSA `= \quad sqrt(( Height (cm) × Weight (Kg) )/(3600))`

    ` \quad \quad \quad = sqrt(( 167.64 \quad cm × 143.9 \quad Kg )/(3600)) = 2.5886 ` m2

  • For Doxorubicin :
    `( 25 \quad mg)/( 1 \quad m^2 )` × 2.5886 m2 × 6 (days of treatment) = 388.29 mg

  • For Mechlorethamine :
    `( 6 \quad mg)/( 1 \quad m^2 )` × 2.5886 m2 × 3 (days of treatment) = 46.59 mg

  • For Vinblastine :
    `( 6 \quad mg)/( 1 \quad m^2 )` × 2.5886 m2 × 6 (days of treatment) = 93.19 mg

`\quad \quad` Therefore,
`\quad \quad \quad` 388.29 mg, 46.59 mg and 93.19 mg `Ans.`

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