T09) Find elimin. rate from Cp and Cl
50. Pharmacokinetics 50.2) Plasma concentrations over time 50.2.1) Plasma concentrations over time
T01: Later plasma concentration Normal 1
Total tried: Correct: Wrong:
If the plasma concentration of a drug is 0.23 mg/L and the clearance is 9.4 L/hr, then calculate the rate of elimination.
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lb equals 2.16 mg/h kg
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For rate of elimination (dX/dt), we can write:
`(dX)/dt = Cp × Cl`
`\implies (dX)/dt = 0.23 \quad (mg)/L × 9.4 \quad L/h`
`∴ (dX)/dt = 2.16 \quad (mg)/h` (Ans).