T09) Find elimin. rate from Cp and Cl

50. Pharmacokinetics 50.2) Plasma concentrations over time 50.2.1) Plasma concentrations over time

T01: Later plasma concentration Normal 1

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If the plasma concentration of a drug is 0.23 mg/L and the clearance is 9.4 L/hr, then calculate the rate of elimination.

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lb equals 2.16 mg/h kg

    For rate of elimination (dX/dt), we can write:
    `(dX)/dt = Cp × Cl`

    `\implies (dX)/dt = 0.23 \quad (mg)/L × 9.4 \quad L/h`

    `∴ (dX)/dt = 2.16 \quad (mg)/h` (Ans).