T11: Mixed problems from T1 - T11.

50. Pharmacokinetics 50.1) PK Basic parameters 50.1.2) Clearance

50.1.2.1) Clearance basic concepts Normal 1


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Determine the elimination rate constant of a drug if its plasma half life is 7.7 h


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lb equals 0.09 h-1 kg

    The relationship between elimination rate constant, `K` and plasma half life, `t_{½}` is, `t_{½}=0.693/K`.
    `Rightarrow K=0.693/t_{½}`
    Plugging the value of `t_{½}` in this equation we get:

    `K = 0.693/(7.7 \quad h)`.

    `therefore` K=0.09 h-1. Ans.


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