Determine PPM from the weight of the drug and weight of total content

3. Percent, Ratio, mg/mL, PPM, PPB 3.4) PPM and PPB 3.4.1) PPM, PPB - General

3.4.1.1) Drug weight from PPM and total Weight Easy 1


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10 Kg of a solution contains 1023 mg of a therapeutic agent. Express the potency in parts per million (PPM) unit.


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lb equals 102.3 PPM kg

    PPM is the number of grams present per 1 million (1,000,000) grams of the mixture. In this case,
    Weight of drug = 1023 mg.
    This should be first converted to gram unit.
    `therefore` Weight of the drug in g unit = `1023/1000=1.023` g.
    Total weight of the mixture = 10 Kg.
    Converting this weight into gram unit:
    Weight in g = `10 × 1000=10000` g.
    Using the formula for PPM, we can write:
    `(1.023 \quad g)/(10000\quad g)=x/(1,000,000\quad g) therefore x = 102.3` g.
    Therefore, the potency is 102.3 PPM. Ans.


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