Determine PPM from the weight of the drug and weight of total content
3. Percent, Ratio, mg/mL, PPM, PPB 3.4) PPM and PPB 3.4.1) PPM, PPB - General
3.4.1.1) Drug weight from PPM and total Weight Easy 1
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31 Kg of a solution contains 1943.7 mg of a therapeutic agent. Express the potency in parts per million (PPM) unit.
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lb equals 62.7 PPM kg
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PPM is the number of grams present per 1 million (1,000,000) grams of the mixture. In this case,
Weight of drug = 1943.7 mg.
This should be first converted to gram unit.
`therefore` Weight of the drug in g unit = `1943.7/1000=1.9437` g.
Total weight of the mixture = 31 Kg.
Converting this weight into gram unit:
Weight in g = `31 × 1000=31000` g.
Using the formula for PPM, we can write:
`(1.9437 \quad g)/(31000\quad g)=x/(1,000,000\quad g) therefore x = 62.7` g.
Therefore, the potency is 62.7 PPM. Ans.