### Regimen: Doxorubicin for an acute myelogenous leukemia (ALL) patient

6. Patient-based Dose 6.5) Chemo Dose Clculation 6.5.2) Intravenous dose of Doxorubicin

6.5.2.1) Intravenous dose per cycle of Doxorubicin Normal 2

Total tried:       Correct:       Wrong:

Regimen : Doxorubicin for an acute myelogenous leukemia (ALL) patient
Cycle: 28 days, repeat for 2-3 cycles

• Doxorubicin, 65 mg/m2, IV , D 1
For doxorubicin calculate total intravenous dose per cycle for a patient measuring 5 feet 2 inches in height and weighing 228 lb.

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lb equals 138.31 mg kg

• The patient height
= 5 feet 2 inches
= ( 5 × 12 + 2 ) inch
= 62 inch
= 62 × 2.54 cm
= 157.48 cm

• patient weight
= 228 lb
= 228 × 0.454 kg
= 103.5 kg

• BSA for the patient is

BSA = \quad sqrt(( Height (cm) × Weight (Kg) )/(3600))

 \quad \quad \quad = sqrt(( 157.48 \quad cm × 103.5 \quad Kg )/(3600)) = 2.1278  m2

• For Doxorubicin :
( 65 \quad mg)/( 1 \quad m^2 ) × 2.1278 m2 × 1 (days of treatment)
= 138.307 mg Ans.