T03) Find C0 from Ct, k and t

50. Pharmacokinetics 50.2) Plasma concentrations over time 50.2.1) Plasma concentrations over time

T01: Later plasma concentration Normal 1


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A 135 -kg patient has received an IV bolus injection of a drug. A sample of blood was collected 6.6 hours after the first collection. The drug follows a first order elimination process, and its elimination rate constant is `0.283 \quad h^{-1}`. If the plasma concentration was 0.156 mg/L in the second sample, then what was the concentration in the initial sample?


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lb equals 1.01 mg/L kg

    For a first order process,
    `C_{t}=C_{0}×e^(-kt)`
    It may be re-organized as:
    `C_{0}=C_{t}/(e^(-kt))`
    Or, `C_{0}=C_{t}×e^(kt)`
    Plugging the values in above equation, we get:
    `C_{0}=0.156 × e^(0.283 × 6.6)`
    `∴ C_{0}=1.01`
    Thus, the initial concentration was: 1.01 mg/L. (Ans).


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