### Regimen: MVAC for bladder cancer

6. Patient-based Dose 6.5) Chemo Dose Clculation 6.5.3) Intravenous dose of MVAC

6.5.3.1) Intravenous dose per cycle of MVAC Normal 1

Total tried:       Correct:       Wrong:

Regimen : MAVC for bladder cancer.
Cycle: 28 days, repeat for 2 - 3 cycles

• Methotrexate, 30 mg/m2, slow IV push, D 1, 15, 22
• Vinblastin, 3 mg/m2, IV , D 2,15,22
• Doxorubicin, 30 mg/m2, slow IV push, D 2
• Cisplatin, 70mg/m2, IV , D 2
For methotrexate and cisplatin calculate total intravenous dose per cycle for a patient measuring 4 feet 8 inches in height and weighing 105 lb.

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lb equals 123.55 mg and 96.10 mg kg

• The patient height
= 4 feet 8 inches
= ( 4 × 12 + 8 ) inch
= 56 inch
= 56 × 2.54 cm
= 142.24 cm

• patient weight
= 105 lb
= 105 × 0.454 kg
= 47.7 kg

• BSA for the patient is

BSA = \quad sqrt(( Height (cm) × Weight (Kg) )/(3600))

 \quad \quad \quad = sqrt(( 142.24 \quad cm × 47.7 \quad Kg )/(3600)) = 1.3728  m2

• For Methotrexate :
( 30 \quad mg)/( 1 \quad m^2 ) × 1.3728 m2 × 3 (days of treatment) = 123.552 mg

• For Cisplatin :
( 70 \quad mg)/( 1 \quad m^2 ) × 1.3728 m2 × 1 (days of treatment) = 96.096 mg

\quad \quad Therefore,
\quad \quad \quad 123.55 mg and 96.10 mg Ans.