### Regimen: MVAC for bladder cancer

6. Patient-based Dose 6.5) Chemo Dose Clculation 6.5.3) Intravenous dose of MVAC

6.5.3.1) Intravenous dose per cycle of MVAC Normal 1

Total tried:       Correct:       Wrong:

Regimen : MAVC for bladder cancer.
Cycle: 28 days, repeat for 2 - 3 cycles

• Methotrexate, 30 mg/m2, slow IV push, D 1, 15, 22
• Vinblastin, 3 mg/m2, IV , D 2,15,22
• Doxorubicin, 30 mg/m2, slow IV push, D 2
• Cisplatin, 70mg/m2, IV , D 2
For methotrexate, doxorubicin and cisplatin calculate total intravenous dose per cycle for a patient measuring 4 feet 10 inches in height and weighing 241 lb.

Click on the button below to see the answer and explanations

lb equals 190.43 mg, 63.48 mg and 148.11 mg kg

• The patient height
= 4 feet 10 inches
= ( 4 × 12 + 10 ) inch
= 58 inch
= 58 × 2.54 cm
= 147.32 cm

• patient weight
= 241 lb
= 241 × 0.454 kg
= 109.4 kg

• BSA for the patient is

BSA = \quad sqrt(( Height (cm) × Weight (Kg) )/(3600))

 \quad \quad \quad = sqrt(( 147.32 \quad cm × 109.4 \quad Kg )/(3600)) = 2.1159  m2

• For Methotrexate :
( 30 \quad mg)/( 1 \quad m^2 ) × 2.1159 m2 × 3 (days of treatment) = 190.431 mg

• For Doxorubicin :
( 30 \quad mg)/( 1 \quad m^2 ) × 2.1159 m2 × 1 (days of treatment) = 63.477 mg

• For Cisplatin :
( 70 \quad mg)/( 1 \quad m^2 ) × 2.1159 m2 × 1 (days of treatment) = 148.113 mg

\quad \quad Therefore,
\quad \quad \quad 190.43 mg, 63.48 mg and 148.11 mg Ans.