Regimen: MVAC for bladder cancer

6. Patient-based Dose 6.5) Chemo Dose Clculation 6.5.3) Intravenous dose of MVAC

6.5.3.1) Intravenous dose per cycle of MVAC Normal 1


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Regimen : MAVC for bladder cancer.
Cycle: 28 days, repeat for 2 - 3 cycles

  • Methotrexate, 30 mg/m2, slow IV push, D 1, 15, 22
  • Vinblastin, 3 mg/m2, IV , D 2,15,22
  • Doxorubicin, 30 mg/m2, slow IV push, D 2
  • Cisplatin, 70mg/m2, IV , D 2
For methotrexate, doxorubicin and cisplatin calculate total intravenous dose per cycle for a patient measuring 4 feet 10 inches in height and weighing 241 lb.


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lb equals 190.43 mg, 63.48 mg and 148.11 mg kg

  • The patient height
    = 4 feet 10 inches
    = ( 4 × 12 + 10 ) inch
    = 58 inch
    = 58 × 2.54 cm
    = 147.32 cm

  • patient weight
    = 241 lb
    = 241 × 0.454 kg
    = 109.4 kg

  • BSA for the patient is

    BSA `= \quad sqrt(( Height (cm) × Weight (Kg) )/(3600))`

    ` \quad \quad \quad = sqrt(( 147.32 \quad cm × 109.4 \quad Kg )/(3600)) = 2.1159 ` m2

  • For Methotrexate :
    `( 30 \quad mg)/( 1 \quad m^2 )` × 2.1159 m2 × 3 (days of treatment) = 190.431 mg

  • For Doxorubicin :
    `( 30 \quad mg)/( 1 \quad m^2 )` × 2.1159 m2 × 1 (days of treatment) = 63.477 mg

  • For Cisplatin :
    `( 70 \quad mg)/( 1 \quad m^2 )` × 2.1159 m2 × 1 (days of treatment) = 148.113 mg

`\quad \quad` Therefore,
`\quad \quad \quad` 190.43 mg, 63.48 mg and 148.11 mg `Ans.`

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