Regimen: MVAC for bladder cancer

6. Patient-based Dose 6.5) Chemo Dose Clculation 6.5.3) Intravenous dose of MVAC

6.5.3.1) Intravenous dose per cycle of MVAC Normal 1


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Regimen : MAVC for bladder cancer.
Cycle: 28 days, repeat for 2 - 3 cycles

  • Methotrexate, 30 mg/m2, slow IV push, D 1, 15, 22
  • Vinblastin, 3 mg/m2, IV , D 2,15,22
  • Doxorubicin, 30 mg/m2, slow IV push, D 2
  • Cisplatin, 70mg/m2, IV , D 2
For methotrexate and cisplatin calculate total intravenous dose per cycle for a patient measuring 4 feet 8 inches in height and weighing 105 lb.


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lb equals 123.55 mg and 96.10 mg kg

  • The patient height
    = 4 feet 8 inches
    = ( 4 × 12 + 8 ) inch
    = 56 inch
    = 56 × 2.54 cm
    = 142.24 cm

  • patient weight
    = 105 lb
    = 105 × 0.454 kg
    = 47.7 kg

  • BSA for the patient is

    BSA `= \quad sqrt(( Height (cm) × Weight (Kg) )/(3600))`

    ` \quad \quad \quad = sqrt(( 142.24 \quad cm × 47.7 \quad Kg )/(3600)) = 1.3728 ` m2

  • For Methotrexate :
    `( 30 \quad mg)/( 1 \quad m^2 )` × 1.3728 m2 × 3 (days of treatment) = 123.552 mg

  • For Cisplatin :
    `( 70 \quad mg)/( 1 \quad m^2 )` × 1.3728 m2 × 1 (days of treatment) = 96.096 mg

`\quad \quad` Therefore,
`\quad \quad \quad` 123.55 mg and 96.10 mg `Ans.`

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