T01) Dose from volume and concentration

50. Pharmacokinetics 50.1) PK Basic parameters 50.1.1) Dose, Volume and Concentration Basic parameters Easy 1

Total tried:       Correct:       Wrong:

How much drug has to be administered to a patient weighing 157 Kg so that the plasma concentration is 3.45 mg/L? Given that, the Volume of distribution of the drug is 0.62 L/Kg.

Click on the button below to see the answer and explanations

lb equals 335.823 mg kg

    Total volume of distribution (V) for this patient will be:
    `0.62 \quad L/(Kg) × 157 \quad Kg = 97.34 \quad L`
    Concentration (`C_{0}`) = `3.45 \quad (mg)/L`;
    Drug quantity (`X_{0}`) =?
    We know that,
    `therefore X_{0} = C_{0} × V`
    `= 3.45 \quad (mg)/L × 97.34 \quad L = 335.823 \quad mg`. Ans.