T01) Creatinine clearance using Cockroft-Gault method

50. Pharmacokinetics 50.2) Plasma concentrations over time 50.2.2) Creatinine clearance

T01: Creatinine Clearance methods Normal 1

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Calculate the creatinine clearance of a 54-year old female patient with 133 lb of weight. The serum creatinine level of the patient is 0.87 mg/dL.

Cockroft-Gault formula:
`CrCl_{m}=(140-Ag e)/(Serum \quad Cr) × (Weight \quad i n \quad Kg)/72`

`CrCl_{f}=CrCl_{m} × 0.85`

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lb equals 70.55 mL/min kg

    Body weight =
    133 lb = `(133 \quad lb)×(1 \quad kg)/(2.2 lb) =60.455 \quad kg`
    This patient is female.
    Therefore, the formula will be:

    `CrCl_{f}=(140-Ag e)/(Serum \quad Cr) × (Weight \quad i n \quad Kg)/72 × 0.85`

    Plugging values in this:

    `CrCl_{f}=(140-54)/(0.87) × (60.455)/72 × 0.85`

    `∴ CrCl_{f}=70.55`

    Thus, the creatinine clearance of this patient is: 70.55 mL/min. (Ans).