T01) Creatinine clearance using Cockroft-Gault method
50. Pharmacokinetics 50.2) Plasma concentrations over time 50.2.2) Creatinine clearance
T01: Creatinine Clearance methods Normal 1
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Calculate the creatinine clearance of a 54-year old female patient with 133 lb of weight. The serum creatinine level of the patient is 0.87 mg/dL.
Cockroft-Gault formula:
`CrCl_{m}=(140-Ag e)/(Serum \quad Cr) × (Weight \quad i n \quad Kg)/72`
`CrCl_{f}=CrCl_{m} × 0.85`
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lb equals 70.55 mL/min kg
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Body weight =
133 lb = `(133 \quad lb)×(1 \quad kg)/(2.2 lb) =60.455 \quad kg`
This patient is female.
Therefore, the formula will be:
`CrCl_{f}=(140-Ag e)/(Serum \quad Cr) × (Weight \quad i n \quad Kg)/72 × 0.85`
Plugging values in this:
`CrCl_{f}=(140-54)/(0.87) × (60.455)/72 × 0.85`
`∴ CrCl_{f}=70.55`
Thus, the creatinine clearance of this patient is: 70.55 mL/min. (Ans).