T01) Creatinine clearance using Cockroft-Gault method
50. Pharmacokinetics 50.2) Plasma concentrations over time 50.2.2) Creatinine clearance
T01: Creatinine Clearance methods Normal 1
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Calculate the creatinine clearance of a 47-year old male patient with 147 lb of weight. The serum creatinine level of the patient is 1.24 mg/dL.
Cockroft-Gault formula:
`CrCl_{m}=(140-Ag e)/(Serum \quad Cr) × (Weight \quad i n \quad Kg)/72`
`CrCl_{f}=CrCl_{m} × 0.85`
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lb equals 69.602 mL/min kg
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Body weight =
147 lb = `(147 \quad lb)×(1 \quad kg)/(2.2 lb) =66.818 \quad kg`
This patient is male.
Plugging values in CG equation:
`CrCl_{m}=(140-Ag e)/(Serum \quad Cr) × (Weight \quad i n \quad Kg)/72`
`∴ CrCl_{m}=(140-47)/(1.24) × (66.818)/72`
`∴ CrCl_{m}=69.602`
Thus, the creatinine clearance of this patient is: 69.602 mL/min. (Ans).