### T01) Creatinine clearance using Cockroft-Gault method

50. Pharmacokinetics 50.2) Plasma concentrations over time 50.2.2) Creatinine clearance

T01: Creatinine Clearance methods Normal 1

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Calculate the creatinine clearance of a 67-year old female patient with 158 lb of weight. The serum creatinine level of the patient is 0.82 mg/dL.

Cockroft-Gault formula:
CrCl_{m}=(140-Ag e)/(Serum \quad Cr) × (Weight \quad i n \quad Kg)/72

CrCl_{f}=CrCl_{m} × 0.85 Click on the button below to see the answer and explanations

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lb equals 75.479 mL/min kg

Body weight =
158 lb = (158 \quad lb)×(1 \quad kg)/(2.2 lb) =71.818 \quad kg
This patient is female.
Therefore, the formula will be:

CrCl_{f}=(140-Ag e)/(Serum \quad Cr) × (Weight \quad i n \quad Kg)/72 × 0.85

Plugging values in this:

CrCl_{f}=(140-67)/(0.82) × (71.818)/72 × 0.85

∴ CrCl_{f}=75.479

Thus, the creatinine clearance of this patient is: 75.479 mL/min. (Ans).

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