T01) Creatinine clearance using Cockroft-Gault method
50. Pharmacokinetics 50.2) Plasma concentrations over time 50.2.2) Creatinine clearance
T01: Creatinine Clearance methods Normal 1
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Calculate the creatinine clearance of a 54-year old male patient with 140 lb of weight. The serum creatinine level of the patient is 0.83 mg/dL.
Cockroft-Gault formula:
`CrCl_{m}=(140-Ag e)/(Serum \quad Cr) × (Weight \quad i n \quad Kg)/72`
`CrCl_{f}=CrCl_{m} × 0.85`
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lb equals 91.578 mL/min kg
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Body weight =
140 lb = `(140 \quad lb)×(1 \quad kg)/(2.2 lb) =63.636 \quad kg`
This patient is male.
Plugging values in CG equation:
`CrCl_{m}=(140-Ag e)/(Serum \quad Cr) × (Weight \quad i n \quad Kg)/72`
`∴ CrCl_{m}=(140-54)/(0.83) × (63.636)/72`
`∴ CrCl_{m}=91.578`
Thus, the creatinine clearance of this patient is: 91.578 mL/min. (Ans).