T01) Creatinine clearance using Cockroft-Gault method

50. Pharmacokinetics 50.2) Plasma concentrations over time 50.2.2) Creatinine clearance

T01: Creatinine Clearance methods Normal 1

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Calculate the creatinine clearance of a 47-year old male patient with 147 lb of weight. The serum creatinine level of the patient is 1.24 mg/dL.

Cockroft-Gault formula:
`CrCl_{m}=(140-Ag e)/(Serum \quad Cr) × (Weight \quad i n \quad Kg)/72`

`CrCl_{f}=CrCl_{m} × 0.85`

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lb equals 69.602 mL/min kg

    Body weight =
    147 lb = `(147 \quad lb)×(1 \quad kg)/(2.2 lb) =66.818 \quad kg`
    This patient is male.
    Plugging values in CG equation:

    `CrCl_{m}=(140-Ag e)/(Serum \quad Cr) × (Weight \quad i n \quad Kg)/72`

    `∴ CrCl_{m}=(140-47)/(1.24) × (66.818)/72`

    `∴ CrCl_{m}=69.602`

    Thus, the creatinine clearance of this patient is: 69.602 mL/min. (Ans).